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Dosage need to be minimized during the aged or debilitated mainly because these clients may be additional sensitive to barbiturates. Dosage really should be diminished for people with impaired renal function or hepatic illness (see Safety measures).

Barbiturates are respiratory depressants. The diploma of respiratory depression is dependent on dose. With hypnotic doses, respiratory melancholy made by barbiturates is comparable to that which takes place during physiologic slumber with slight minimize in blood pressure level and heart amount.

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